Pre-clinical (normoalbuminuria)
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(新頁面: *Urinary albumin excretion< 30 mg/g creatinine *< 5 year, renal hypertrophy, hyperfiltration, intrarenal hypertension, thick GBM (cannot predict progression), loss of heparan sulfate (neg...)
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在2018年3月27日 (二) 12:48所做的修訂版本
- Urinary albumin excretion< 30 mg/g creatinine
- < 5 year, renal hypertrophy, hyperfiltration, intrarenal hypertension, thick GBM (cannot predict progression), loss of heparan sulfate (negative charge)-->albuminuria
- Mesangial expansion/sclerosis (PAS+)
- Pathogenesis
- Glomerular hypertension, hyperfiltration, proteinuria, hyperglycemia, advanced glycosylation end products, growth hormone, atrial natriuretic peptide, insulin-like growth factor I, angiotensin II (efferent arteriole constriction), connective tissues growth factor, transforming growth factor-&b, hyperlipidemia